A INFLUÊNCIA DA RADIOTERAPIA E DA QUIMIOTERAPIA NA INTERAÇÃO ENTRE O SISTEMA IMUNE E OS CÂNCERES

Autores

  • Nathália Moisés Neves UNIFESP
  • Eliane Cardoso Silva Uninove
  • Giovana Benichel Bilancieri Uninove
  • Eliazar Da Silva Santos Júnior Uninove
  • João Carlos Zamae Rodrigues Universidade Vale do Salgado

Palavras-chave:

Imunovigilância. Quimioterapia. Radioterapia.

Resumo

Os cânceres são um grupo de doenças caracterizadas pela proliferação celular desordenada. Os
tratamentos indicados variam de acordo com a classificação das neoplasias e incluem a quimioterapia e a
radioterapia. A morte celular decorrente dessas terapias resulta em inflamação que pode colaborar ou se opor ao
desenvolvimento tumoral. Neste artigo expomos essas interações e de quais fatores depende cada um desses dois
desfechos.

Biografia do Autor

Nathália Moisés Neves, UNIFESP

Graduanda do curso de medicina da Universidade Federal Paulista (UNIFESP)

Eliane Cardoso Silva, Uninove

Graduanda do curso de medicina da Universidade Nove de Julho (Uninove)

Giovana Benichel Bilancieri, Uninove

Graduanda do curso de medicina da Universidade Nove de Julho (Uninove)

Eliazar Da Silva Santos Júnior, Uninove

Graduando do curso de medicina da Universidade Nove de Julho (Uninove)

João Carlos Zamae Rodrigues, Universidade Vale do Salgado

Docente e coordenador do curso de medicina veterinária

Especialista, mestre e doutor em patologia animal.

Especialista em oncologia veterinária.

Referências

AGGARWAL, B. B.; VIJAYALEKSHMI, R. V.; SUNG, B. Targeting Inflammatory

Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe.

Clinical Cancer Research, v. 15, n. 2, p. 425–430, 15 jan. 2009.

HANAHAN, D.; WEINBERG, R. A. Hallmarks of Cancer: The Next Generation.

Cell, v. 144, n. 5, p. 646–674, 4 mar. 2011.

JAROSZ-BIEJ, M. et al. Tumor Microenvironment as A “Game Changer†in Cancer

Radiotherapy. International Journal of Molecular Sciences, v. 20, n. 13, 29 jun. 2019.

FORMENTI, S. C.; DEMARIA, S. Systemic effects of local radiotherapy. The

Lancet. Oncology, v. 10, n. 7, p. 718–726, jul. 2009.

JEREMIC, B. (ED.). Advances in Radiation Oncology in Lung Cancer. Berlin

Heidelberg: Springer-Verlag, 2005.

GRIVENNIKOV, S. I.; GRETEN, F. R.; KARIN, M. Immunity, inflammation, and

cancer. Cell, v. 140, n. 6, p. 883–899, 19 mar. 2010.

GRIVENNIKOV, S. I.; KARIN, M. Inflammatory cytokines in cancer: tumour

necrosis factor and interleukin 6 take the stage. Annals of the Rheumatic Diseases, v. 70

Suppl 1, p. i104-108, mar. 2011.

DENKERT, C. et al. Tumor-Associated Lymphocytes As an Independent Predictor of

Response to Neoadjuvant Chemotherapy in Breast Cancer. Journal of Clinical Oncology, v.

, n. 1, p. 105–113, 16 nov. 2009.

SIEGEL, R. L.; MILLER, K. D.; JEMAL, A. Cancer statistics, 2015. CA: a cancer

journal for clinicians, v. 65, n. 1, p. 5–29, fev. 2015.

BAXEVANIS, C. N.; PEREZ, S. A. Cancer Dormancy: A Regulatory Role for

Endogenous Immunity in Establishing and Maintaining the Tumor Dormant State. Vaccines,

v. 3, n. 3, p. 597–619, 30 jul. 2015.

PAUKEN, K. E.; WHERRY, E. J. Overcoming T cell exhaustion in infection and

cancer. Trends in Immunology, v. 36, n. 4, p. 265–276, abr. 2015.

BRENNECKE, P. et al. Inflammatory and Innate Immune Cells in Cancer

Microenvironment and Progression. In: REZAEI, N. (Ed.). . Cancer Immunology: A

Translational Medicine Context. Berlin, Heidelberg: Springer, 2015. p. 9–28.

SCHREIBER, R. D.; OLD, L. J.; SMYTH, M. J. Cancer Immunoediting: Integrating

Immunity’s Roles in Cancer Suppression and Promotion. Science, v. 331, n. 6024, p.

–1570, 25 mar. 2011.

SHANKARAN, V. et al. IFNgamma and lymphocytes prevent primary tumour

development and shape tumour immunogenicity. Nature, v. 410, n. 6832, p. 1107–1111, 26

abr. 2001.

HIRAOKA, K. et al. Concurrent infiltration by CD8+ T cells and CD4+ T cells is a

favourable prognostic factor in non-small-cell lung carcinoma. British Journal of Cancer, v.

, n. 2, p. 275–280, 30 jan. 2006.

HALD, S. M. et al. CD4/CD8 co-expression shows independent prognostic impact in

resected non-small cell lung cancer patients treated with adjuvant radiotherapy. Lung Cancer

(Amsterdam, Netherlands), v. 80, n. 2, p. 209–215, maio 2013.

SOUKUP, K.; WANG, X. Radiation meets immunotherapy – a perfect match in the

era of combination therapy? International Journal of Radiation Biology, 2015.

CAO, X. Regulatory T cells and immune tolerance to tumors. Immunologic

Research, v. 46, n. 1–3, p. 79–93, mar. 2010.

DERER, A. et al. Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis

for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and

Ongoing Clinical Applications. Frontiers in Immunology, v. 6, p. 505, 2015.

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Publicado

2020-12-30

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